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Why Does Otezla Cause Weight Loss? Understanding the Mechanism

Title: Why Does Otezla Cause Weight Loss? Understanding the Mechanism


When it comes to⁣ managing certain ⁣chronic conditions such as psoriasis or psoriatic arthritis, Otezla has become ​a popular medication due to its effectiveness in alleviating symptoms. However, one surprising side effect that some users may experience is weight loss. In this article, we will delve into the mechanism behind why ⁣Otezla can lead​ to weight loss and explore the factors contributing to this effect.

What is Otezla?

Otezla, also known by its generic name Apremilast, is a‍ medication that is commonly prescribed to treat psoriasis and psoriatic arthritis. It works by targeting specific⁤ enzymes involved in the inflammatory‌ process, thereby reducing inflammation and improving symptoms associated with these conditions.

How ⁤Does Otezla Cause⁢ Weight ⁣Loss?

The primary ​reason why Otezla can result in weight loss is due to⁢ its impact on the appetite and metabolism of the individual. Some of the key mechanisms through which Otezla influences weight loss include:

  1. Appetite Suppression: Otezla has been shown ​to reduce appetite in some individuals, leading to a decrease in caloric intake. ⁣This can result in weight loss over time as the individual consumes fewer calories than‌ they expend.

  2. Metabolic Changes: Otezla⁤ may also affect the metabolism of the individual, potentially⁢ leading to ⁤an increase‌ in energy expenditure. This can promote weight loss by burning more calories than usual, even without significant changes in diet or exercise habits.

  3. Gastrointestinal Side Effects: Otezla can cause gastrointestinal side effects such as⁤ nausea,‍ diarrhea, or vomiting in some individuals.‌ These symptoms may⁤ impact‌ the absorption of ​nutrients from food, contributing to weight loss.

Benefits of Otezla-Induced Weight Loss:

While unintentional weight loss may not‍ be ⁣the primary goal of Otezla treatment, there are some potential ‍benefits associated with this side effect. These include:

  • Improved Body​ Image: For individuals struggling with excess weight, the unintended weight loss from Otezla treatment may‌ lead to improvements in body image and self-esteem.

  • Reduced Disease Burden: ​ Weight loss can have a positive impact on certain‍ chronic conditions ​such as psoriasis and psoriatic arthritis​ by reducing the burden on ⁢the joints and skin.

Practical Tips for Managing Weight Loss with‌ Otezla:

If you are​ experiencing ‌weight loss while taking Otezla, it ⁢is essential to consult with your healthcare provider to address any⁤ concerns. Some practical tips for managing weight loss with Otezla include:

  • Monitor Your Weight: Keep track of your weight regularly to ensure that any changes are within a healthy range.

  • Maintain a Balanced Diet: ⁣Focus on consuming a balanced diet rich in nutrients to support your overall health and well-being.

  • Stay Active: Incorporate regular physical ​activity into your routine to help ‍maintain muscle ‍mass and‌ support a⁢ healthy metabolism.


While weight loss may be an unexpected side effect of Otezla treatment, understanding the mechanisms behind this phenomenon can help individuals navigate this aspect of their healthcare journey. By staying informed, communicating⁤ with healthcare providers, and implementing practical ⁣tips for managing weight loss,⁢ individuals can optimize their overall well-being while undergoing treatment⁣ with Otezla.



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